| Catalog number | PB9569 |
|---|---|
| Name | Eotaxin Antibody |
| Size | 0,1 mg |
| Price | 374.00 EUR |
| Supplier | boster |
| Order | |
| Extended details | |
| Target antigen | Eotaxin |
| Clonality | Polyclonal antibody |
| Clone | Polyclonal antibody |
| Raised in | rabbit |
| Type of the antibody | IgG polyclonal antibody |
| Product form | freeze-dried |
| Reacts with species: | human, mouse, rat |
| Analyses | WB,ELISA |
| Immunogen | E. coli-derived human Eotaxin recombinant protein (Position: G24-P97). Human Eotaxin shares 61.6% and 63% amino acid (aa) sequence identity with mouse and rat Eotaxin, respectively. |
| Product configuration | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3. |
| Purification | Immunogen affinity purified. |
| Solubilization | The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml |
| Storage condtions | Keep the Eotaxin Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way. |
| Tips | The Eotaxin Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics. |
| Background | CCL11 (Chemokine (C-C motif) ligand 11), also known as Eotaxin, is a small cytokine belonging to the CC chemokine family. Eotaxin selectively recruits eosinophils by inducing their chemotaxis, and therefore, is implicated in allergic responses. The effects of Eotaxin are mediated by its binding to a G-protein-linked receptor known as a chemokine receptor. Chemokine receptors for which Eotaxin is a ligand include CCR2, CCR3 and CCR5. However, it has been found that eotaxin-1 (CCL11) has high degree selectivity for its receptor, such that they are inactive on neutrophils and monocytes, which do not express CCR3. The gene for human Eotaxin is encoded on three exons and is located on chromosome 17q12. |
| Related articles | 1. Menzies-Gow, A., Ying, S., Sabroe, I., Stubbs, V. L., Soler, D., Williams, T. J., Kay, A. B.Eotaxin (CCL11) and eotaxin-2 (CCL24) induce recruitment of eosinophils, basophils, neutrophils, and macrophages as well as features of early- and late-phase allergic reactions following cutaneous injection in human atopic and nonatopic volunteers.J. Immun. 169: 2712-2718, 2002. 2. Shin, H. D., Kim, L. H., Park, B. L., Jung, J. H., Kim, J. Y., Chung, I.-Y., Kim, J. S., Lee, J. H., Chung, S. H., Kim, Y. H., Park, H.-S., Choi, J. H., Lee, Y. M., Park, S. W., Choi, B. W., Hong, S.-J., Park, C.-S.Association of eotaxin gene family with asthma and serum total IgE.Hum. Molec. Genet. 12: 1279-1285, 2003. Note: Erratum: Hum. Molec. Genet. 12: 2083 only, 2003. 3. Villeda, S. A., Luo, J., Mosher, K. I., Zou, B., Britschgi, M., Bieri, G., Stan, T. M., Fainberg, N., Ding, Z., Eggel, A., Lucin, K. M., Czirr, E., and 11 others.The ageing systemic milieu negatively regulates neurogenesis and cognitive function.Nature 477: 90-94, 2011. |
| Gene Name | CCL11 |
| Protein Name | Eotaxin |
| Gene Full Name | chemokine (C-C motif) ligand 11 |
| Synonyms | C-C motif chemokine 11 antibody|CCL 11 antibody|CCL11 antibody|CCL11_HUMAN antibody| chemokine (C-C motif) ligand 11 antibody| Chemokine C C motif ligand 11 antibody|Chemokine CC Motif Ligand 11 antibody|Chemokine ligand 11 antibody|Eosinophil Chemotactic Protein antibody|Eotaxin antibody|eotaxin-1 antibody|MGC22554 antibody|SCYA 11 antibody|SCYA11 antibody|Small inducible cytokine A11 antibody|Small inducible cytokine subfamily A (Cys Cys) member 11 antibody|small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin) antibody|Small inducible cytokine subfamily A member 11 antibody|Small-inducible cytokine A11 antibody |
| Uniprot ID | P51671 |
| Entrez GeneID | 6356 |
| Properties | If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. |
| French translation | anticorps |