Information
| Catalog number |
PKSH032194-10µg |
| Name |
Recombinant Human C-C Motif Chemokine 26/CCL26(27-94) Protein |
| Size |
10µg |
| Price |
241.00 EUR |
| Supplier |
Elabscience
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|
Order
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| Synonym |
C-C Motif Chemokine 26; CC Chemokine IMAC; Eotaxin-3; Macrophage Inflammatory Protein 4-Alpha; MIP-4-Alpha; Small-Inducible Cytokine A26; Thymic Stroma Chemokine-1; TSC-1; CCL26; SCYA26 |
| Activity |
NA |
| Sequence |
Ser27-Leu94 |
| Fusion tag |
NA |
| Accession |
Q9Y258 |
| Expressed Host |
E.coli |
| Shipping |
The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| Purity |
＞95% as determined by reducing SDS-PAGE. |
| Endotoxin |
＜1.0 EU per µg as determined by LAL test. |
| Stability and Storage |
Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months |
| Mol Mass |
8.2 kDa |
| AP Mol Mass |
13 kDa |
| Formulation |
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2. |
| Background |
Chemokine (C C Motif) Ligand 26 (CCL26) is a novel small cytokine belonging to the CC chemokine family, which involved in immunoregulatory and inflammatory processes. CCL26 is expressed constitutively in thymus, but only transiently in phytohemagglutinin-stimulated peripheral blood mononuclear cells. It specifically binds and induces chemotaxis in T cells and elicits its effects by interacting with the chemokine receptor CCR4. Eotaxin-3/CCL26, along with Eotaxin-1 and Eotaxin-2, selectively activates the CC chemokine receptor 3 (CCR3). The Eotaxin-3-CCR3 interaction may play an important role in allergic diseases such as atopic dermatitis and bronchial asthma. The full-length cDNA for Eotaxin-3 encodes a protein of 94 amino acids with a putative signal peptide of either 23 or 26 amino acid residues. Both the 71 and 68 amino acid residue variants of recombinant Eotaxin-3 demonstrate equal potency in inducing chemotaxis of a human CCR3-transfected cell line. Unlike most other CC chemokines, Eotaxin-3 maps to human chromosome 7q11.2, within 40 kilobases of the Eotaxin-2 loci. Eotaxin-3 and Eotaxin-2 are unique in that they are the only chemokines identified to date that map to chromosome 7. |
| Description |
Chemokines, chemokine receptors, ligands , motif chemokines and cytokines are supplied by Elabscience in 1. |
| Properties |
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples. |
| Source |
Recombinants or rec. proteins |
| Group |
recombinants |